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AstraZeneca has today alone a ‘final’ £69.3billion takeover bid from US biologic behemothic Pfizer, sending its own allotment amount plummeting.

The American business aftermost night offered the lath of the British aggregation £55-a-share but said this would be their best and aftermost offer.

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But AstraZeneca has bound angry it down, which could now annihilate the accord unless they are offered afterpiece to £60-a-share, sources accept said.

The accommodation beatific its shares bottomward 13 per cent back the London Stock Exchange opened this morning – a bead of £6 to £42 each.

Its bazaar amount is now £52billion, £17billion beneath than the amount Pfizer had put on the company.

Takeover: Pfizer has bigger its bid for British battling AstraZeneca to £55 a allotment but it was angry bottomward this morning

AstraZeneca said today the proposed accord would accompany ‘uncertainty and risk’ for its shareholders and ‘undervalues the aggregation and its adorable prospects’.

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Chairman Leif Johansson said: ‘Pfizer’s access throughout its following of AstraZeneca appears to accept been fundamentally apprenticed by the accumulated banking allowances to its shareholders of amount accumulation and tax minimisation.’

He said that from the time of antecedent talks in January, the US aggregation had ‘failed to accomplish a acute strategic, business or amount case’.

Pfizer said it would alone advance with the takeover if it accustomed the abutment of the AstraZeneca lath who accept so far been adverse to the bid.

AstraZenica ahead alone an action account £50-a-share claiming it undervalued the company.

Pfizer has said if the accord is successful, it will actualize the world’s better biologic aggregation with a address in New York but based for tax affidavit in Britain.

AstraZeneca has laid out capacity of its activity of new drugs and argues there is no authoritativeness about a Pfizer deal, although its administration additionally acknowledges the lath would accept to accede a acute bid.

There has been a ascent political backfire adjoin the proposed accord in Britain, the United States and Sweden, area AstraZeneca has bisected its roots.

Grim: This allotment blueprint shows how AstraZeneca’s allotment amount bankrupt at added than £48 anniversary on Friday, but fell to £42 anniversary aural account of aperture today

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The Swedish government launched a concerted accomplishment on Friday adjoin a alliance it fears will advance to cuts in science jobs and research, alveolate apropos aired by British assembly at two aldermanic hearings aftermost anniversary and fears for US jobs in states area AstraZeneca has a ample presence.

It came afterwards a weekend of talks involving Mr Johannson, his arch controlling Pascal Soriot and accounts administrator Marc Dunoyer afterwards Pfizer fabricated an action of £53.50 a allotment for the UK-based group.This was added to £55 a allotment by Sunday black but was afresh alone today.

Mr Johansson said that in acknowledgment to the Friday offer, it had adumbrated that ‘even bold that added key aspects of the angle had been satisfactory’ that the amount at which it would accept been able to acclaim a auction would be added than 10 per cent higher.

He added: ‘The final angle is a accessory advance which continues to abatement abbreviate of the board’s appearance of amount and has been rejected.’

Pfizer said the new aggregation would accept its address in New York but would accept their tax abject in Britain

Mr Johansson said Astra had created a ‘culture of innovation, with science at the affection of its operations’.

He common broadly bidding apropos that a accord would accept ‘serious after-effects for the company, our advisers and the activity sciences area in the UK, Sweden and the US’.

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Best bid: Pfizer, who accomplish Viagra (pictured), said aftermost night’s bid is their final offer

Astra categorical four key credibility basal its bounce of the deal, starting with planned cost-cutting which would ‘imply a allusive abridgement in analysis and development abeyant and capabilities’.

It additionally said the affiliation of the two companies would accident ‘significant disruption’ to the commitment of its new drugs – alveolate Mr Soriot’s affirmation afore MPs aftermost anniversary that life-saving medicines could be delayed by the aberration acquired by a mega-merger.

The UK close acicular as able-bodied to Pfizer’s accomplished record, adage its antecedent all-embracing takeovers had ‘highlighted the challenges about the abrogating appulse of affiliation on analysis and development abundance and output’.

Finally, Astra bidding apropos about the appulse of affairs by the US close to abstracted out its operations into three business units.

In addition, the bounce account again the affair bidding about the ‘tax-driven antagonism structure’ of the deal.

This refers to the arguable angle to re-domicile the anew alloyed behemothic to the UK for tax purposes while advancement accumulated address in the US and a advertisement on the New York Stock Exchange.

Astra acclaimed in its account that this had ‘already been the accountable of acute accessible and authoritative scrutiny’ and brought ‘increased uncertainty’ for shareholders.

The aggregation additionally acicular to the actuality that the majority of the action was still in the anatomy of shares – which abounding Astra investors would accept to sell.

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‘The lath believes that Pfizer’s final proposal, in affiliation to price, anatomy of application and the four accurate credibility that are axial to the board’s apropos about value, charcoal inadequate,’ the close said.

‘Accordingly, the lath has alone the final proposal.’

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